Everton midfielder Jean-Philippe Gbamin will be out for at least six months after injuring an Achilles tendon in training on Thursday.
The 24-year-old Ivory Coast international signed from German side Mainz for £25m last summer.
He only started one Premier League game after picking up a thigh problem that eventually required surgery.
Earlier this week Gbamin said he had hoped he could figure again before the end of this campaign.
He had been working at Everton's Finch Farm training headquarters after manager Carlo Ancelotti's squad returned to prepare for the proposed resumption of the Premier League in June.
Gbamin had been doing ball work with his team-mates and was hoping to join in full sessions soon, saying: "We are taking it slowly because it was a big injury. It was not easy but if I think if the games start to be played in the Premier League then I think I can play."
Now, after this latest major setback, there are fears it could be another nine months before the highly rated Gbamin will be in contention for competitive action.
The UK has been in lockdown now for just over two months. In that time, we have missed lots of things - friends, family, pubs, popular high street pasty chains.
We've also missed our favourite footballers.
Nevertheless, in a way, it feels like we've got to know some of them better than ever, as they've let us into their homes - with broadcast group calls on IGLive and streamed yoga lessons.
Many footballers have shown off new or hidden talents - from dancing, to playing the piano, to juggling toilet rolls.
Here are just some things we've learned…
Ashley Young can grow hair
Perhaps the best kept secret of all time. To think - all these years, he was bald by choice. Who knew?!
Cristiano Ronaldo cares what you think
At least when it comes to taking a new tonsorial direction.
Marcus Rashford is officially a good egg
We knew it all along. Now it's in writing.
As is Jose Mourinho
Don't ever tell us that the spiky Portuguese manager doesn't have a soft side.
Lewandowski cannot dance
Please Robert - do not tarnish our image of you!
Wayne Bridge, on the other hand, definitely CAN dance
It's also worth mentioning that he looks pretty good in mustard
Sergio Ramos also has a sensitive, musical side
There's something very sweet and boyish about this Grade 1 piano style rendition from one of the most controversial figures in the game. Is there a coded message in there though? Louis Armstrong? Strong-arm? Like how he strong-armed Mohamed Salah in the 2018 Champions League final.
Paddy Kirk is a musical genius
That's Paddy Kirk the Bohemians left-back, not Paddy Kirk the Emmerdale character, just for clarification.
Gerrard and Lovren don't go easy on children
The former Liverpool man here practising the art of what's called, in the business, an early reducer - letting the opposition know that you mean business.
To clarify, by 'early', we mean three years old.
To be fair, he's got the ball there…
Trent is the comeback king
First that corner against Barcelona and now this big scalp.
Dominic Calvert-Lewin developed a new 'comedy routine' with Bob Mortimer
The young Everton striker has received a lot of plaudits this season - he's the Toffees' top scorer, with 15 goals and one assist so far. However, even his partnership with Richarlison has impressed us perhaps less than this potential partnership with a British comedy legend. Train (at home) Guy is the new comedy character we want and need.
Gini Wijnaldum has hidden depths
The midfield maestro has been brave enough to share his art with us during lockdown, putting himself on the line the way he does with his team.
Patrice Evra is expert-level on Photoshop
He's basically a one-man content production house by now, so we shouldn't really be surprised to learn that he's also pretty talented when it comes to photo-editing, but this face-swap has been one of our favourite things on the internet during this whole period.
Shkodran Mustafi proved he has the ability to grow
We all make mistakes Shkodran and the important thing here is that he saw the error of his ways.
The Arsenal centre-back also showed off that he's a super dad.
Any parents who have had to combine working from home with teaching phonics to a five-year-old during lockdown will surely admire the versatility and resourcefulness displayed here by the German international.
Alex Oxlade-Chamberlain invented a new way to brush the floor
Klopp likes a man with quick feet and The Ox has proven that he's not slowing down during the break from training.
James Milner knows how to occupy himself
They say that only boring people get bored and 'boring James Milner' has certainly shown during this lockdown that he can fruitfully find ways to entertain himself while stuck in the house - whether that's by conjuring up his dream XI (above)…
…planning rations for the week…
…or keeping his lawn tidy.
David Luis also enjoys his own company
The great defenders make it seem like they're in two places at once, don't they?
The veteran Brazilian defender reached another milestone during lockdown and we're glad he wasn't left to celebrate alone…
New chant: 'We all dream of a team of David Luis, a team of David Luis, a team of David Luis!'
Everyone did the toilet roll challenge
The 'toilet roll challenge' was the major trend of lockdown week one, as footballer and others everywhere struggled to find a use for the mountains of roll that they had stockpiled.
Starlet Phil Foden showed incredible control with the shoulder….
And Chelsea's Ramona Bachmann took it up a notch…
And then everyone did the tea challenge
Lockdown week two came along and, presumably, people had started using their toilet roll for the stuff it was intended for. There was a new trick in town.
Mbwana Samatta takes two sugars (not sure that was signed off by the club nutritionist)…
And the less said about Harry Winks' brewing methods, the better - the bag's still in lad!
Seems like a long time ago now, all that, doesn't it? Actual football in three weeks? Let's hope so.
Manchester City vs Arsenal and Aston Villa vs Sheffield United will kick off the resumed campaign on 17 June.
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And it has been revealed that all the remaining fixtures will be televised across Sky Sports, BT Sport, BBC and Amazon Prime with supporters not allowed to return to stadiums for the foreseeable future.
Premier League Chief Executive Richard Masters said: “Today we have provisionally agreed to resume the Premier League on Wednesday 17 June.
“But this date cannot be confirmed until we have met all the safety requirements needed, as the health and welfare of all participants and supporters is our priority.
“Sadly, matches will have to take place without fans in stadiums, so we are pleased to have come up with a positive solution for supporters to be able to watch all the remaining 92 matches.
“The Premier League and our clubs are proud to have incredibly passionate and loyal supporters. It is important to ensure as many people as possible can watch the matches at home.
“We will continue to work step-by-step and in consultation with all our stakeholders as we move towards resuming the 2019/20 season.”
The weekend schedule will see games on Friday and Monday evenings as well in four time slots on Saturdays and Sundays.
Midweek matches will be played on Tuesdays, Wednesdays and Thursdays with two kick-off slots each.
The BBC will show four live games, the first time the broadcaster has ever televised a Premier League game live since its inception in 1992.
BBC director of sport Barbara Slater said: “This opportunity creates an historic moment for the BBC and our audiences.
“At a time when sports fans across the country are in need of a lift, this is very welcome news. We are delighted and excited to have the chance to show live Premier League games on the BBC.
“This will offer audiences, who haven’t had the opportunity in the past, live, free to air access to the best football league in the world, as the BBC continues to keep the country entertained during these unprecedented times.”
And in another landmark move Sky will make 25 of their games free-to-air in a first for the corporation, including Everton vs Liverpool in the Merseyside derby on the opening weekend.
Sky CEO and EVP, UK and Europe, Stephen van Rooyen said: “The return of live sport is a big moment for the country, and we want the nation to join us.
“Sky has partnered with the Premier League and its clubs for nearly thirty years, and the strength of our partnership has never been more important.
“Our commitment to showing 25 matches ‘free to air’ for the first time in the history of Sky Sports recognises the unique times we are in, and our desire to play our part.”